Persistance of Cognitive Enhancement. Nefiracetam, Tacrine (galantamine) and Deprenyl
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Persistance of Cognitive Enhancement. Nefiracetam, Tacrine (galantamine) and Deprenyl
Very interesting results in this article from the American College of Neuropsychopharmacology.
They were testing the persistance of cognition enhancement obtained from the use of nefiracetam, deprenyl (for neuroprotection) and tacrine (similar in action to Galantamine).
Partial abstract:
"Recent data suggest that Alzheimer's patients who discontinue treatment with cholinesterase inhibitors have a significantly delayed cognitive decline as compared to patients receiving placebo. Such observations suggest cholinesterase inhibitors to provide a disease-modifying effect as well as symptomatic relief and, moreover, that this benefit remains after drug withdrawal. Consistent with this suggestion, we now demonstrate that chronic administration of tacrine, nefiracetam, and deprenyl, drugs that augment cholinergic function, increases the basal frequency of dentate polysialylated neurons in a manner similar to the enhanced neuroplasticity achieved through complex environment rearing."
Bottom-line except from the article:
"Our observations are consistent with the idea that a chronic drug regimen or a complex environment induces a more robust memory pathway that can acquire and consolidate new information more efficiently. This hypothesis finds support in the improved learning behavior and enhanced resistance to cholinergic deficits seen following either intervention. Furthermore, the level of enhancement of basal neuroplastic status achieved by either drug or environmental intervention correlates directly with improved spatial learning ability. "
You can read the full article by clicking here. 188kb PDF
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