Which Resveratrol to take?

[PeteH]

So much controversy right now on resveratrol. Many suppliers have existing or revamped products. Given the bioavailability issues, which is currently the best supplement to take and why?

What is the best form of the material to take?

Is is stable after regular encapsulation or must it be a sealed gelcap?

I would love to add resveratrol to the Relentless Improvement store, but honestly do not know how to approach this tricky material. Doing my own product is certainly an option, but I want to get it right!

Pete

[Addison Strack]

I want to get it right!


Plant based resveratrol appears reasonably stable with standard good manufacturing practices.


1: J Med Food. 2006 Spring;9(1):11-4.

Resveratrol and its glycon piceid are stable polyphenols.

Prokop J, Abrman P, Seligson AL, Sovak M.

Interpharma Praha, a.s., Prague, Czech Republic.

Plant extracts containing phytopolyphenols, including resveratrol, are
extensively used as nutraceutical supplements. Recent reports allege their lack
of stability at ambient conditions. We have studied the stability of resveratrol
and its glycon piceid in a mixture with a whole grape extract for 2 years
(long-term stability) under Good Manufacturing Practice pharmaceutical protocols
(at 60% humidity and 25 degrees C). The neat compounds were followed for 4 years
under conditions of "accelerated stability," at 75% humidity and 40 degrees C,
all in the presence of ambient air. Chromatographic analysis did not detect any
instability, thus disproving the claims to the opposite. No storage precautions
are necessary for these nutritional supplements.

PMID: 16579722 [PubMed - indexed for MEDLINE]


If you offered capsules containing a guaranteed 100-200 mg TRANS-resveratrol with a reasonably low emodin content at a decent price, no matter what else is in it, you'd do fine. Most people will probably want 100mg-500mg trans-resveratrol per day, and a few will want more.

The other option is synthetic, pure trans-resveratrol, which can more easily degrade with heat and light, and may be more expensive. This would be appealing because you can offer the same exact substance as used in the mouse studies, and because no manufacturer seems to be able to reliably list on the bottle just how much trans-resveratrol is in their product. To avoid degredation, you'd probably want to distribute it as a bulk powder with a scoop, possibly in vacuum sealed bottles or bags. You might also be able to get the jump on everyone who is waiting for the next harvest of knotweed. The pure powder is pretty much tasteless, so people could keep it in their fridge and scoop it into their mouth or into drinks just fine. In the product description, you'd def. want a dosing guide to allow people to mimick the amounts used in mouse studies, so they can realize just how much they need to take.

If you go that road, I'd mimick Paul Wakfur's powder purchase option, but do it as an experienced businessman instead of as a guy trying to get a bulk purchase order together where he is personally bagging stuff and offering no guarantee. You'd probably find plenty of the bulk customers.

I'd go with bottling your own plant extract in three or four months when the new harvest is available following standard GMP and offering a test showing emodin and trans-res content, with an eye towards what other manufacturers are charging.

Then, after high dose resveratrol becomes more popular, I'd take the plunge and get some artificial stuff synthesized to copy wakfur.

Then again, if you can't bottle plant extract price-competitively with country life or the other large encapsulators, I'd just stick to copying wakfur's bulk purchase plan and selling bulk powder from Orchid Pharma. The market is about to become super-saturated with resveratrol.

[Porthose]

Hi Pete,

I've been taking Longevinex Resveratrol for nearly a year. I know its more expensive than other brands out there but what really sold me was the fact that they have posted a lot of information on their website on the product ie manufacturing, quality etc etc.

If you do go down the road to making the stuff, I would be your first customer!

Good luck!

Peter

[PeteH]

Good stuff, thank you very much for the feedback. Working on this project right now, along with some others.

[phalexo]

There are a lot of claims by companies that they provide "stable" resveratrol.
Consider the following: Cis-resveratrol readily changes at high percentages
into its trans isomer in low pH (1). Guess what the pH of your stomach is, yes
it is in fact between 1 and 2. Also it is not really relevant if the company kept
it in freezing temperatures once it hits your stomach it is going to be at
98F or so. One should look for purity, no solvents, and other gunk but
your stomach acid will immediately convert any cis isomer to trans no matter
what the percentage was when it arrived at your door step.

So, paying extra for so-called stabilization of trans isomer seems foolish.







Hi Pete,

I've been taking Longevinex Resveratrol for nearly a year. I know its more expensive than other brands out there but what really sold me was the fact that they have posted a lot of information on their website on the product ie manufacturing, quality etc etc.

If you do go down the road to making the stuff, I would be your first customer!

Good luck!

Peter

[Porthose]

Hi Pete,

I was wondering if you've had any progress on manufacturing your own resveratrol product?

thanks.

[akash1s]

Pete - It looks like AOR has a new resveratrol product out. Will you be selling this?

Regards, Akash

[PeteH]

Progress being made on a high mg per capsule, low emodin content (0.0004%) product. Still at least several months away though. If AOR makes their new Resveratrol product available in the USA (not all of their products are shipped here) I may carry it in the interim.

Pete

[PeteH]

No luck on getting AOR's product :-(

Progress is being made however on a Relentless Improvement brand Resveratrol. Interesting dose, bottle quantity, and pricing :-) Stay tuned.

Pete

[PeteH]

Now in stock, 300 mg transresveratrol (http://resveratrol.org). Low emodin means no laxative effect. I, and others here at RI, have used this up to 4 capsules at once so far (1200 mg ) with no gastrointestinal effects whatsoever. You can also find us at Resveratrol (http://resveratrol.org).org. Order our Resveratrol supplement (http://www.nexternal.com/relentless/Product286)at this link. This is static page for resveratrol (http://www.relentlessimprovement.com/catalog/resveratrol.htm).

[PeteH]

The new Relentless Improvement brand documented Resveratrol (http://resveratrol.org) is a hit. No gastrointestinal upsets, no gas, no bloating, no laxative effect. If you choose a high dose resveratrol (http://www.relentlessimprovement.com/catalog/resveratrol.htm) regimen, you must use a low emodin product of suffer some very uncomfortable side-effects.

With deep quantity discounts, we are doing all we can to help you afford a 98% pure resveratrol extract.

In stock, shipping same day. Order Relentless Improvement brand Resveratrol (http://www.nexternal.com/relentless/Product286) online today.

Anecdotal customer comments include greater energy, sense of increased endurance, inflammation reduction. Try it for 3 months and see how you feel.

Pete